Important Safety Information for Zepbound
Zepbound, containing Tirzepatide as its active ingredient, is specifically formulated as a dual-action GLP-1/GIP receptor agonist. This medication is FDA-approved for individuals with obesity (BMI ≥30) or overweight (BMI ≥27) who also have a weight-related condition. Zepbound is intended to be used alongside dietary modifications and regular exercise as part of a comprehensive approach to weight management.
As with any medication, it’s important to be aware of the potential risks and benefits associated with Zepbound and to use it under the guidance of a qualified healthcare provider. Regular monitoring and communication with your healthcare provider can help ensure the safe and effective use of compounded medications in your treatment regimen.
What is Zepbound Used For?
Zepbound is an injectable prescription medication designed to aid adults with obesity or those who are overweight and have weight-related medical conditions in losing weight and maintaining weight loss. It should be used in combination with a reduced-calorie diet and increased physical activity.
Warning: Risk of Thyroid C-Cell Tumors
Zepbound has been linked to thyroid tumors, including thyroid cancer, in rats. It is currently unknown whether Zepbound could cause thyroid tumors or medullary thyroid carcinoma (MTC) in humans. Inform your provider if you experience a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath, as these may be signs of thyroid cancer.
Do not use Zepbound if you or any of your family members have a history of medullary thyroid carcinoma (MTC) or have been diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Who Should Take Zepbound?
Zepbound is FDA-approved for chronic weight management in adults who meet one of the following criteria:
- A body mass index (BMI) of 30 or higher (classified as obesity).
- A BMI of 27 or higher with a weight-related health condition, such as high blood pressure, high cholesterol, type 2 diabetes, obstructive sleep apnea, or heart disease.
Before prescribing Zepbound, your healthcare provider will review your personal and family medical history and ask for a list of any medications or supplements you are currently taking. This is to ensure that Zepbound is safe for you, as certain health conditions may increase the risk of using this medication. For example, Zepbound should not be used by individuals who are pregnant, breastfeeding, or planning to become pregnant. Additionally, it is contraindicated in people with severe gastrointestinal diseases.
How Should Zepbound be Administered?
Each box of Zepbound includes four single-dose prescription pens. To administer Zepbound, you inject the medication subcutaneously into your abdomen, thigh, or upper arm once a week, rotating the injection site with each dose. The medication is available in six different dosage strengths. Typically, healthcare providers recommend starting with a low dose of 2.5 milligrams (mg) weekly, then increasing the dose by 2.5 mg every four weeks until reaching a maintenance dose of 5 mg, 10 mg, or 15 mg.
Foods to Avoid While Taking Zepbound
No foods are known to dangerously interact with Zepbound. However, reducing or eliminating some of the following foods and drinks may help alleviate side effects and improve your success with Zepbound.
- Fried and greasy foods
- Sugary sweets and treats
- Refined carbohydrates
- Carbonated beverages
- Alcohol
Common Side Effects of Zepbound
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Indigestion
- Injection site reactions (such as rash)
- Fatigue
- Belching
- Hair loss
- Gastroesophageal reflux disease (GERD)
Most Serious Side Effects of Zepbound
For many people, Zepbound is a safe and effective medication for weight loss. In rare cases, however, it may cause serious side effects. These include:
- Severe gastrointestinal disease
- Acute kidney injury
- Acute gallbladder disease
- Acute pancreatitis
- Allergic reaction to Zepbound
- Hypoglycemia (low blood sugar)
- Diabetic retinopathy (vision loss or damage in people with type 2 diabetes)
- Depression or suicidal thoughts
People with type 2 diabetes or a history of kidney or gallbladder problems may be at increased risk of experiencing these side effects, so be sure to tell your healthcare provider about any underlying health conditions prior to starting Zepbound. They can adjust your dosages of insulin to avoid hypoglycemia or recommend other safety measures to avoid potential side effects.
Note
Please note that these warnings serve to highlight specific risks associated with Zepbound and are not comprehensive. Healthcare providers should review the full prescribing information for Zepbound and consider individual patient factors before prescribing this medication. Patients should consult their healthcare provider for personalized guidance and recommendations regarding the use of Zepbound and the management of any potential risks.
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