Safety Information

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Ozempic is a prescription medication containing the active ingredient semaglutide, which belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. It is used to improve blood sugar control in adults with type 2 diabetes mellitus. Ozempic works by mimicking the action of a natural hormone called GLP-1, which helps regulate blood sugar levels. 

By activating GLP-1 receptors in the body, Ozempic helps stimulate insulin secretion, reduce glucagon secretion, and slow down gastric emptying, ultimately leading to lower blood sugar levels. It is typically administered once weekly by subcutaneous injection and is often used alongside other diabetes medications and lifestyle modifications such as diet and exercise.

As with any medication, it’s important to be aware of the potential risks and benefits associated with Ozempic and to use it under the guidance of a qualified healthcare provider. Regular monitoring and communication with your healthcare provider can help ensure the safe and effective use of compounded medications in your treatment regimen.

What is Ozempic Used For?

The FDA-approved uses of Ozempic include:

  • Improving glycemic control in patients with type 2 diabetes mellitus, in conjunction with diet and exercise.
  • Reducing the risk of major adverse cardiovascular events in patients with type 2 diabetes mellitus and established cardiovascular disease.

It’s important to note the following limitations of use:

  • Ozempic has not been studied in patients with a history of pancreatitis.
  • Ozempic is not intended for the treatment of type 1 diabetes mellitus.

Additionally, your provider may recommend the use of Ozempic for chronic weight management (obesity or overweight).

Warning: Risk of Thyroid C-Cell Tumors

Studies involving mice and rats have shown that semaglutide, the active ingredient in Ozempic and Wegovy, led to the development of thyroid tumors, including thyroid cancer. It is uncertain whether Ozempic will have a similar effect in humans, potentially causing thyroid tumors or medullary thyroid carcinoma (MTC). If you notice a lump or swelling in your neck, or experience hoarseness, difficulty swallowing, or shortness of breath, promptly inform your healthcare provider, as these symptoms could indicate thyroid cancer.

Avoid using Ozempic if you or any of your family members have a history of medullary thyroid carcinoma (MTC) or if you have a condition affecting the endocrine system called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Who Should Not Take Ozempic?

Individuals who should not take Ozempic include:

  • Those with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Anyone with a known hypersensitivity or allergic reaction to semaglutide or any of the ingredients in Ozempic.

It’s important for individuals to discuss their medical history and any potential contraindications with their healthcare provider before starting treatment with Ozempic.

How Should Ozempic be Administered?

  • Ozempic should be administered via subcutaneous injection once weekly.
  • The injection can be given into the abdomen, thigh, or upper arm.
  • Follow the dosing instructions provided by the healthcare provider.
  • Patients should receive proper training on the injection technique.
  • Rotation of injection sites is recommended to minimize the risk of injection site reactions.

Foods to Avoid While Taking Ozempic

While taking Ozempic, it’s important to be mindful of certain dietary considerations to optimize its effectiveness and minimize potential side effects. Here are some foods to avoid while taking Ozempic:

  • Consuming meals high in fat content may delay the absorption of Ozempic and increase the risk of gastrointestinal side effects such as nausea and diarrhea. 
  • Drinking excessive amounts of alcohol while taking Ozempic may increase the risk of hypoglycemia (low blood sugar).

Common Side Effects of Ozempic

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Constipation

Most Serious Side Effects of Ozempic

You or a caregiver must diligently monitor for these potential adverse reactions, especially when starting treatment or adjusting doses.

Thyroid C-Cell Tumors:
Ozempic carries a warning regarding the potential risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). Although rare, individuals should be vigilant for symptoms such as a lump or swelling in the neck, hoarseness, difficulty swallowing, or shortness of breath, which could indicate thyroid cancer.

Hypersensitivity Reactions:
Severe allergic reactions to Ozempic may occur, characterized by symptoms such as rash, itching, swelling of the face, lips, or throat, and difficulty breathing. Immediate medical attention is necessary if these symptoms occur.

In rare cases, Ozempic may cause inflammation of the pancreas (pancreatitis), which can lead to severe abdominal pain, nausea, vomiting, and fever. Patients should promptly report any such symptoms to their healthcare provider.

Diabetic Retinopathy Complications:
Individuals with type 2 diabetes may experience worsening of diabetic retinopathy, leading to changes in vision. Any alterations in vision should be reported to a healthcare provider.

Ozempic can lower blood sugar levels, potentially leading to hypoglycemia. Symptoms include dizziness, sweating, confusion, and rapid heartbeat. Patients should monitor their blood sugar levels closely and be aware of these symptoms.

Acute Kidney Injury:
Dehydration due to gastrointestinal side effects associated with Ozempic use may exacerbate kidney problems. Adequate fluid intake is important to reduce the risk of dehydration.

Cardiovascular Events:
While Ozempic is used to reduce the risk of cardiovascular events in patients with type 2 diabetes and established cardiovascular disease, some cardiovascular events such as heart attacks or strokes may still occur. Patients should promptly report any symptoms suggestive of cardiovascular events to their healthcare provider.


Please note that these warnings serve to highlight specific risks associated with Ozempic and are not comprehensive. Healthcare providers should review the full prescribing information for Ozempic and consider individual patient factors before prescribing this medication. Patients should consult their healthcare provider for personalized guidance and recommendations regarding the use of Ozempic and the management of any potential risks.